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Phenotypes Associated with This Genotype
Genotype
MGI:5570963
Allelic
Composition		 Cx3cr1tm3(Hbegf)Litt/Cx3cr1tm3(Hbegf)Litt
Tg(Itgax-cre)1-1Reiz/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm3(Hbegf)Litt mutation (1 available); any Cx3cr1 mutation (47 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:210086 )
• mice treated with diphtheria toxin (DTR) and infected with non-invasive Salmonella exhibit decreased bacterial titers in the mesenteric lymph nodes as compared to mice carrying Cx3cr1tm3(DTR)Litt in the absence of cre recombinase

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory