Phenotypes Associated with This Genotype

Genotype
MGI:5569821

• Allelic Composition: Tg(AGER)#Eca/0
• Genetic Background: C57BL/6J-Tg(AGER)#Eca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

decreased lung endothelial cell proliferation ( J:205092 )

• cell proliferation is reduced in lung epithelia at the beginning of the alveolarization phase compared to controls which show an increase in proliferation

lung inflammation ( J:205092 )

• from 10-18 months of age, inflammatory cell infiltration is seen with loss of alveolar structures

abnormal lung morphology ( J:205092 )

• mice show an increase in the number of TUNEL-positive cells in the lungs at P4, P8, P20, and P30, indicating increased apoptosis

abnormal lung alveolus development ( J:205092 )

• altered alveolarization process and a reduction in secondary alveolar crest formation

abnormal pulmonary alveolar system morphology ( J:205092 )

• the volume density ratio of secondary alveolar crests/lung parenchyma in the lungs is lower than in controls, indicating a decrease in secondary crest volume density

• from 10-18 months of age, mice show progressive loss of alveolar structures

dilated pulmonary alveolar duct ( J:205092 )

• increase in size of alveolar ducts

overexpanded pulmonary alveolus ( J:205092 )

• lungs show diffuse airspace enlargement at P4

abnormal pulmonary interalveolar septum morphology ( J:205092 )

• lungs show short or absent secondary septa at P4

• increase in apoptosis in the alveolar septa

emphysema ( J:205092 )

• reduction of the number of alveolar septa and an increase in size of the alveolar ducts results in developmental emphysema

abnormal pulmonary elastic fiber morphology ( J:205092 )

• alveolar elastic fibers are fragmented, thin, not well-organized and distributed in the alveolar wall with an unraveled and loose appearance

immune system

lung inflammation ( J:205092 )

• from 10-18 months of age, inflammatory cell infiltration is seen with loss of alveolar structures

cellular

decreased lung endothelial cell proliferation ( J:205092 )

• cell proliferation is reduced in lung epithelia at the beginning of the alveolarization phase compared to controls which show an increase in proliferation