Analysis Tools
homeostasis/metabolism
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• mice fed standard chow or a high fat diet exhibit normal insulin tolerance
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• in a hyperglycemic clamp study, mice fed standard chow exhibit a higher glucose infusion rate compared with wild-type mice
• mice exhibit reduced STZ-induced hyperglycemic effect compared with wild-type mice
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• in mice fed standard chow during the hyperglycemic clamp studies
• in STZ-treated mice
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• slightly in fasting mice fed standard chow
• in mice fed a high fat diet
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• in mice fed standard chow or a high fat diet
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growth/size/body
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• in mice fed standard chow
• in STZ-treated mice
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• mice exhibit are protected from STZ-induced weight loss compared with wild-type mice
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cellular
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• in mice fed standard chow
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endocrine/exocrine glands
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• beta cells contain increased insulin granules
• however, beta cell size is normal
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• in mice fed standard chow
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• in mice fed standard chow
• in STZ-treated mice
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• mice are protected from STZ-induced beta cell loss via apoptosis compared with wild-type mice
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• in mice fed standard chow
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• in mice fed standard chow during the hyperglycemic clamp studies
• in STZ-treated mice
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