Phenotypes Associated with This Genotype

Genotype
MGI:5569625

• Allelic Composition: Htr2c^tm2Jke/Htr2c^tm2Jke; Tg(Pomc-cre/ERT2)#Jke/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased food intake ( J:207704 )

♀ • daily food intake is increased in chow-fed mice given tamoxifen at 11 weeks and monitored from 12-20 weeks

growth/size/body

growth/size/body region phenotype ( J:207704 )

♀N • mice given tamoxifen at 11 weeks and switched to a high fat, high sugar (HFHS) diet 1 week after exhibit higher body weights after 6 weeks on the HFHS diet

increased body weight ( J:207704 )

♀ • mice given tamoxifen at 11 weeks and switched to a high fat, high sugar (HFHS) diet 1 week later exhibit higher body weights after 6 weeks on the HFHS diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207704 )

♀N • chow-fed mutants receiving tamoxifen at 11 weeks do not show changes in respiratory exchange ratio or physical activity from 12-20 weeks

♀N • tamoxifen-treated mutants that are switched to a high fat, high sugar (HFHS) diet exhibit hyperphagia but do not show a further increase in VO2 and VCO2

increased circulating glucose level ( J:207704 )

♀ • two weeks after tamoxifen treatment, chow-fed mutants have elevated levels

increased circulating glucagon level ( J:207704 )

♀ • two weeks after tamoxifen treatment, chow-fed mutants have elevated levels

increased circulating insulin level ( J:207704 )

♀ • hyperinsulinemia is observed 4 weeks after tamoxifen treatment in chow-fed mutants

increased oxygen consumption ( J:207704 )

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