Phenotypes for Cd79a Ssb MGI:5569496 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ssb^tm1Rjma/Ssb^tm2.1Rjma Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: 129S/SvEv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Ssb^tm1Rjma mutation (0 available); any Ssb mutation (30 available)
Ssb^tm2.1Rjma mutation (0 available); any Ssb mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:207687 )

N	• mice exhibit normal splenic CD4+ and CD8+ T cells

arrested B cell differentiation ( J:207687 )

• total block at the pro-B cell to pre-B cell transition

decreased B cell number ( J:207687 )

• severe

small spleen ( J:207687 )

• hyposplenia

decreased spleen weight ( J:207687 )

decreased IgG level ( J:207687 )

• absent

decreased IgM level ( J:207687 )

• absent

hematopoietic system

arrested B cell differentiation ( J:207687 )

• total block at the pro-B cell to pre-B cell transition

decreased B cell number ( J:207687 )

• severe

small spleen ( J:207687 )

• hyposplenia

decreased spleen weight ( J:207687 )

decreased IgG level ( J:207687 )

• absent

decreased IgM level ( J:207687 )

• absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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