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Phenotypes Associated with This Genotype
Genotype
MGI:5568509
Allelic
Composition		 Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+
Cd79atm3(cre/ERT2)Reth/Cd79a+
Tg(BCL2)22Wehi/0
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm3(cre/ERT2)Reth mutation (2 available); any Cd79a mutation (22 available)
Gt(ROSA)26Sortm1(ETV6/SYK)Hjum mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(BCL2)22Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:208904 )
• severe after tamoxifen treatment
abnormal plasma cell differentiation ( J:208904 )
• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
abnormal B cell physiology ( J:208904 )
• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment
enlarged lymph nodes ( J:208904 )
• severe after tamoxifen treatment

hematopoietic system
enlarged spleen ( J:208904 )
• severe after tamoxifen treatment
abnormal plasma cell differentiation ( J:208904 )
• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
abnormal B cell physiology ( J:208904 )
• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment

growth/size/body
enlarged spleen ( J:208904 )
• severe after tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory