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Phenotypes Associated with This Genotype
Genotype
MGI:5567830
Allelic
Composition		 Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Hprt1tm1(Ins2-HBEGF)Herr/Y
Tg(Gcg-rtTA)#Herr/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1062 available)
Hprt1tm1(Ins2-HBEGF)Herr mutation (0 available); any Hprt1 mutation (1280 available)
Tg(Gcg-rtTA)#Herr mutation (0 available)
Tg(tetO-cre)1Jaw mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic alpha cell differentiation ( J:159291 )
• alpha cells in diphtheria-treated mice transdifferentiate into beta cells

cellular
abnormal pancreatic alpha cell differentiation ( J:159291 )
• alpha cells in diphtheria-treated mice transdifferentiate into beta cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory