Phenotypes Associated with This Genotype

Genotype
MGI:5567003

• Allelic Composition: Lep^ob/Lep^ob; Nfe2l2^tm1Mym/Nfe2l2^tm1Mym
• Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:208590 )

• 4 of 34 mice fed normal chow die between 8 and 12 weeks of severe metabolic disorders (extreme hyperglycemia, dark yellow urine and very low body weight)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208590 )

N • mice fed normal chow exhibit the same skeletal muscle triglycerides and plasma free glycerol and free fatty acid levels as in Lep^ob homozygotes

hyperglycemia ( J:208590 )

• in mice fed normal chow compared with Lep^ob homozygotes

• extreme in 4 of 34 mice fed normal chow that die between 8 and 12 weeks

increased circulating triglyceride level ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

insulin resistance ( J:208590 )

• in mice fed normal chow compared with Lep^ob homozygotes

• in white adipose tissue of mice fed normal chow compared with Lep^ob homozygotes

decreased liver triglyceride level ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

abnormal urine color ( J:208590 )

• dark yellow urine in 4 of 34 mice fed normal chow that die between 8 and 12 weeks

adipose tissue

decreased white adipose tissue amount ( J:208590 )

• in mice fed normal chow compared with Lep^ob homozygotes

abnormal adipose tissue development ( J:208590 )

• impaired adipogenesis as determined by expression of adipogenic and anti-oxidant response genes compared with Lep^ob homozygotes

abnormal white fat cell morphology ( J:208590 )

• fewer small adipocytes in mice fed normal chow compared to in Lep^ob homozygotes

growth/size/body

decreased body weight ( J:208590 )

• from 5 through 11 weeks in mice fed normal chow compared with Lep^ob homozygotes

• very low body weight in 4 of 34 mice fed normal chow that die between 8 and 12 weeks

decreased susceptibility to weight gain ( J:208590 )

• in mice fed normal chow compared with Lep^ob homozygotes

behavior/neurological

decreased food intake ( J:208590 )

♀ • in female mice fed normal chow after 10 weeks compared with Lep^ob homozygotes

liver/biliary system

decreased liver triglyceride level ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

hepatic steatosis ( J:208590 )

• mild with fewer, smaller lipid droplets in mice fed normal chow compared to in Lep^ob homozygotes

renal/urinary system

abnormal urine color ( J:208590 )

• dark yellow urine in 4 of 34 mice fed normal chow that die between 8 and 12 weeks