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Phenotypes Associated with This Genotype
Genotype
MGI:5566535
Allelic
Composition		 Rbm20tm2.1Hgra/Rbm20+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbm20tm2.1Hgra mutation (0 available); any Rbm20 mutation (54 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber morphology ( J:208676 )
• reduced stiffness under passive stress
abnormal heart left ventricle morphology ( J:208676 )
• prolonged deceleration time of the E wave suggests a reduced diastolic left ventricular chamber stiffness

homeostasis/metabolism
abnormal exercise endurance ( J:208676 )
• increased maximal running speed on a free-running wheel
• however, mean running distance is normal

muscle
abnormal myocardial fiber morphology ( J:208676 )
• reduced stiffness under passive stress

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory