Rbm20^tm2.1Hgra
Targeted Allele Detail

Summary

• Symbol: Rbm20^tm2.1Hgra
• Name: RNA binding motif protein 20; targeted mutation 2.1, Henk Granzier
• MGI ID: MGI:5564779
• Synonyms: cRBM20^deltaRRM
• Gene: Rbm20 Location: Chr19:53665737-53855511 bp, + strand Genetic Position: Chr19, 48.28 cM
• Alliance: Rbm20^tm2.1Hgra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208676
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 6 and 7 were floxed. The neomycin resistance cassette in the original targeting vector was removed. (J:208676)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm20 Mutation: 51 strains or lines available

References

• Original: J:208676 Methawasin M, et al., Experimentally increasing titin compliance in a novel mouse model attenuates the frank-starling mechanism but has a beneficial effect on diastole. Circulation. 2014 May 13;129(19):1924-36
• All: 3 reference(s)