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Phenotypes Associated with This Genotype
Genotype
MGI:5564982
Allelic
Composition
Tg(KRT14-Il4)#Lsch/0
Genetic
Background
involves: BALB/cBy * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mild spongiosis in early and chronic inflammatory lesions
• early inflammatory lesions show a dermal and epidermal infiltration of mononuclear cells and actively degranulating mast cells in the dermis
• chronic inflammatory lesions show prominent dermal mononuclear cell infiltration, dermal eosinophil infiltration, and mast cell degranulation
• prominent epidermal and dermal infiltrate of CD3+ T cells in early inflammatory lesions
• in crusting skin lesions, epidermis is absent and is replaced by serous materials and numerous neutrophils
• 17 of 40 mice develop dermatitis within a 12 month period
• skin lesions are characterized by chronic dermatitis, mononuclear cell infiltration, and mast cell degranulation
• in chronic inflammatory lesions
• focal areas of parakeratosis in chronic inflammatory lesions
• in both early and chronic inflammatory lesions
• xerosis is seen at 4 months of age
• inflammatory skin lesions surface around 4 months of age
• skin lesions initially occur at the ears and subsequently extend to the neck, mouth, around the eyes, tail and legs
• 100% of mice show ear lesions, 65% show neck lesions, 53% show lesions around the eyes, 29% show lesions on the face, 12% show tail lesions, 12% show leg lesions and 6% show lesions on the torso
• skin lesions appear to be pruritic, with mice showing constant face rubbing and scratching

behavior/neurological
• skin lesions appear to be pruritic, with mice showing constant face rubbing and scratching

immune system
• mast cell degranulation in skin lesions
• total serum IgG2a levels are slightly reduced
• early inflammatory lesions show a dermal and epidermal infiltration of mononuclear cells and actively degranulating mast cells in the dermis
• chronic inflammatory lesions show prominent dermal mononuclear cell infiltration, dermal eosinophil infiltration, and mast cell degranulation
• prominent epidermal and dermal infiltrate of CD3+ T cells in early inflammatory lesions
• in crusting skin lesions, epidermis is absent and is replaced by serous materials and numerous neutrophils
• 17 of 40 mice develop dermatitis within a 12 month period
• skin lesions are characterized by chronic dermatitis, mononuclear cell infiltration, and mast cell degranulation
• infection of the skin lesions occurs following self-inflicted excoriation which slowly destroys the external ears
• 47% of mice develop bacterial pyoderma at the external ear
• inflammatory skin lesions precede the onset of pyoderma

hematopoietic system
• mast cell degranulation in skin lesions
• total serum IgG2a levels are slightly reduced

homeostasis/metabolism
• mild spongiosis in early and chronic inflammatory lesions

vision/eye
• eyelid dermatitis, blepharitis, and conjunctivitis result in corneal and conjunctival scarring
• eyelid dermatitis, blepharitis, and conjunctivitis result in corneal and conjunctival scarring
• eyelid dermatitis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
atopic dermatitis DOID:3310 OMIM:603165
OMIM:PS603165
J:126285


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory