Phenotypes for Isl1 Smo MGI:5563905 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Smo^tm2Amc/Smo^tm2Amc Isl1^tm1(cre)Tmj/Isl1⁺
Genetic Background	involves: 129S/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (38 available)
Smo^tm2Amc mutation (2 available); any Smo mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

blood vessel atresia ( J:204743 )

• embryos show severe inflow tract defects with pulmonary vein atresia

persistent truncus arteriosus ( J:204743 )

abnormal heart right ventricle morphology ( J:204743 )

• embryos show severe inflow tract defects with pulmonary vein atresia

abnormal blood circulation ( J:204743 )

• embryos show persistence of aortopulmonary collateral circulation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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