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Phenotypes Associated with This Genotype
Genotype
MGI:5563689
Allelic
Composition		 Il18tm1Aki/Il18tm1Aki
Tg(KRT14-CASP1)1Miz/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il18tm1Aki mutation (4 available); any Il18 mutation (31 available)
Tg(KRT14-CASP1)1Miz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgE level ( J:78602 )
• low serum IgE levels
decreased IgG1 level ( J:78602 )
• low serum IgG1 levels

immune system
immune system phenotype ( J:78602 )
N
• diminution in the number of cutaneous mast cells and serum histamine levels compared to single Tg(KRT14-CASP1)1Miz mice
decreased IgE level ( J:78602 )
• low serum IgE levels
decreased IgG1 level ( J:78602 )
• low serum IgG1 levels

integument
integument phenotype ( J:78602 )
N
• mice do not exhibit frequent skin scratching nor dermatitis by 6 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory