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Phenotypes Associated with This Genotype
Genotype
MGI:5563543
Allelic
Composition		 Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb1tm1.1Ttg mutation (0 available); any Hmgb1 mutation (16 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased circulating interleukin-1 beta level ( J:205499 )
• following lipopolysaccharide stimulation
increased circulating interleukin-18 level ( J:205499 )
• following lipopolysaccharide stimulation

homeostasis/metabolism
increased circulating interleukin-1 beta level ( J:205499 )
• following lipopolysaccharide stimulation
increased circulating interleukin-18 level ( J:205499 )
• following lipopolysaccharide stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory