Phenotypes Associated with This Genotype

Genotype
MGI:5563459

• Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:204263 )

• some pIpC-treated mice die prematurely from T lineage acute lymphoblastic leukemia

hematopoietic system

enlarged spleen ( J:174880 , J:204263 )

• marked splenomegaly 2 days after pIpC induction (J:174880)

• in pIpC-treated mice (J:204263)

abnormal definitive hematopoiesis ( J:204263 )

• cells from pIpC-treated mice exhibit cytokine-independent CFU-GM growth and pronounced GM-CSF hypersensitivity compared with control cells

abnormal myelopoiesis ( J:174880 )

• display a myeloproliferative phenotype 2 days after pIpC induction

myeloid hyperplasia ( J:204263 )

• all pIpC-treated mice exhibit overt myeloproliferative neoplasm

anemia ( J:204263 )

• in pIpC-treated mice

increased leukocyte cell number ( J:204263 )

• in pIpC-treated mice

increased neutrophil cell number ( J:204263 )

• in pIpC-treated mice

increased monocyte cell number ( J:204263 )

• in pIpC-treated mice

neoplasm

increased acute lymphoblastic leukemia incidence ( J:204263 )

• some pIpC-treated mice die prematurely from T lineage acute lymphoblastic leukemia

immune system

enlarged spleen ( J:174880 , J:204263 )

• marked splenomegaly 2 days after pIpC induction (J:174880)

• in pIpC-treated mice (J:204263)

abnormal myelopoiesis ( J:174880 )

• display a myeloproliferative phenotype 2 days after pIpC induction

myeloid hyperplasia ( J:204263 )

• all pIpC-treated mice exhibit overt myeloproliferative neoplasm

increased leukocyte cell number ( J:204263 )

• in pIpC-treated mice

increased neutrophil cell number ( J:204263 )

• in pIpC-treated mice

increased monocyte cell number ( J:204263 )

• in pIpC-treated mice

growth/size/body

enlarged spleen ( J:174880 , J:204263 )

• marked splenomegaly 2 days after pIpC induction (J:174880)

• in pIpC-treated mice (J:204263)