Phenotypes Associated with This Genotype

Genotype
MGI:5563351

• Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub; Fas^lpr/Fas^lpr
• Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased spleen weight ( J:204782 )

• severe at 6 months

abnormal B cell number ( J:204782 )

• reduced percentage total B cells

abnormal T cell number ( J:204782 )

• marked increased percentage of lpr T cells in the spleen, lymph nodes and peritoneal cavity

• increased percentage of total T cells

enlarged lymph nodes ( J:204782 )

• severe at 6 months

autoimmune response ( J:204782 )

increased anti-chromatin antibody level ( J:204782 )

increased anti-double stranded DNA antibody level ( J:204782 )

• more so than in Cd72^tm1Tsub homozygotes

increased anti-single stranded DNA antibody level ( J:204782 )

• more so than in Cd72^tm1Tsub homozygotes

liver inflammation ( J:204782 )

• more so than in either single homozygotes

glomerulonephritis ( J:204782 )

• with immune complex deposition, more so than in either single homozygotes

lung inflammation ( J:204782 )

• more so than in either single homozygotes

renal/urinary system

glomerulonephritis ( J:204782 )

• with immune complex deposition, more so than in either single homozygotes

renal glomerular immunoglobulin deposits ( J:204782 )

liver/biliary system

liver inflammation ( J:204782 )

• more so than in either single homozygotes

respiratory system

lung inflammation ( J:204782 )

• more so than in either single homozygotes

hematopoietic system

increased spleen weight ( J:204782 )

• severe at 6 months

abnormal B cell number ( J:204782 )

• reduced percentage total B cells

abnormal T cell number ( J:204782 )

• marked increased percentage of lpr T cells in the spleen, lymph nodes and peritoneal cavity

• increased percentage of total T cells

growth/size/body

increased spleen weight ( J:204782 )

• severe at 6 months