Phenotypes Associated with This Genotype

Genotype
MGI:5563203

• Allelic Composition: Shank3^tm1.1Pfw/Shank3^tm1.1Pfw
• Genetic Background: B6.129S6-Shank3^tm1.1Pfw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:204162 )

N • do not show communication deficits or abnormalities in startle response

photophobia ( J:204162 )

• remarkable increase in avoidance of a brightly lit chamber in a dark/light chamber assay spending almost the entire 10 min assay time in the dark chamber

• however, mice do not show increased anxiety-like behaviors in elevated plus maze or open field assays, suggesting this is an avoidance of light rather than an anxiety-like behavior

impaired spatial learning ( J:204162 )

• in a Morris water maze

• in a reversal learning water maze test mice fail to show any preference for the new target location in the probe trial

abnormal spatial reference memory ( J:204162 )

• in a reversal learning water maze test mice fail to show any preference for the new target location in the probe trial

abnormal innate avoidance response ( J:204162 )

• remarkable increase in avoidance of a brightly lit chamber in a dark/light chamber assay spending almost the entire 10 min assay time in the dark chamber

• however, mice do not show increased anxiety-like behaviors in elevated plus maze or open field assays, suggesting this is an avoidance of light rather than an anxiety-like behavior

abnormal response to novelty ( J:204162 )

• show no preference for social novelty versus familiarity

decreased exploration in new environment ( J:204162 )

• decrease locomotor behavior for the first 5 min in a novel home cage, this rapidly reverts to wild-type levels after the first 5 min

abnormal response to novel object ( J:204162 )

• fail to interact with inanimate objects in nest building and marble burying assays

• interact significantly less with an inanimate object in a three-chamber social interaction assay

increased grooming behavior ( J:204162 )

• increase in grooming and time spent per grooming bout in older (10-13 months of age) but not younger (9-18 weeks of age) mice

abnormal motor coordination/balance ( J:204162 )

♀ • increased swim speed in females

impaired coordination ( J:204162 )

• decrease in latency to fall in a rotarod assay

decreased thermal nociceptive threshold ( J:204162 )

• decreased latency in a hotplate assay

abnormal social investigation ( J:204162 )

• show no preference for social novelty versus familiarity

nervous system

nervous system phenotype ( J:204162 )

N • the number and structure of CA1 pyramidal neuron synaptic spines are similar to controls

abnormal excitatory postsynaptic currents ( J:204162 )

• the input/output relationship of stimulus intensity to slope of the fEPSP is decreased

abnormal glutamate-mediated receptor currents ( J:204162 )

• decrease in the NMDA/AMPA ratio in hippocampal synapses

reduced long-term potentiation ( J:204162 )

• significantly impaired

abnormal miniature excitatory postsynaptic currents ( J:204162 )

• frequency is significantly decreased; however, amplitude is similar to controls

growth/size/body

decreased body weight ( J:204162 )

• at about 17 weeks of age

homeostasis/metabolism

photophobia ( J:204162 )

• remarkable increase in avoidance of a brightly lit chamber in a dark/light chamber assay spending almost the entire 10 min assay time in the dark chamber

• however, mice do not show increased anxiety-like behaviors in elevated plus maze or open field assays, suggesting this is an avoidance of light rather than an anxiety-like behavior

vision/eye

photophobia ( J:204162 )

• remarkable increase in avoidance of a brightly lit chamber in a dark/light chamber assay spending almost the entire 10 min assay time in the dark chamber

• however, mice do not show increased anxiety-like behaviors in elevated plus maze or open field assays, suggesting this is an avoidance of light rather than an anxiety-like behavior