Phenotypes Associated with This Genotype

Genotype
MGI:5560657

• Allelic Composition: Mef2a^tm1.1Limm/Mef2a^tm1.1Limm; Mef2c^tm2Eno/Mef2c^tm2Eno; Mef2d^tm3Eno/Mef2d^tm3Eno; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:207812 )

• partial lethality by 5 weeks

nervous system

nervous system phenotype ( J:207812 )

N • mice exhibit normal numbers of spines per length of dendrite in pyramidal neurons

increased neuron apoptosis ( J:207812 )

• 5-fold

decreased brain size ( J:207812 )

abnormal long-term potentiation ( J:207812 )

• mice exhibit decreased input-output curve compared with wild-type mice

• however, long term potentiation is normal

enhanced paired-pulse facilitation ( J:207812 )

growth/size/body

decreased body weight ( J:207812 )

cellular

increased neuron apoptosis ( J:207812 )

• 5-fold