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Phenotypes Associated with This Genotype
Genotype
MGI:5559184
Allelic
Composition		 Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(Nphs1-rtTA*3G)8Jhm/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(tetO-EGFP/Rac1*)Shaw mutation (0 available); any Hprt1 mutation (1280 available)
Tg(Nphs1-rtTA*3G)8Jhm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:206088 )
N
• glomeruli are unremarkable
increased urine protein level ( J:206088 )
• doxycycline-treated mice exhibit proteinuria that peaks at 4 days and decreases gradually over time unlike control mice

homeostasis/metabolism
increased urine protein level ( J:206088 )
• doxycycline-treated mice exhibit proteinuria that peaks at 4 days and decreases gradually over time unlike control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory