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Phenotypes Associated with This Genotype
Genotype
MGI:5559061
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Krastm4Tyj mutation (11 available); any Kras mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased adenocarcinoma incidence ( J:125101 )
• intranasal instillation of an adenovirus expressing Cre recombinase (Ad-Cre) results in the development of sinonasal adenocarcinomas
• however, mice injected intramuscularly with Ad-Cre into the extremities or uterus do not develop soft tissue sarcomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory