Phenotypes Associated with This Genotype

Genotype
MGI:5559031

• Allelic Composition: Memo1^tm1.1Neh/Memo1^tm1.1Neh; Tg(CAG-cre/Esr1*)1Lbe/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:206626 )

• in tamoxifen-treated mice

reproductive system

azoospermia ( J:206626 )

♂ • in tamoxifen-treated mice

abnormal sex gland morphology ( J:206626 )

• small gonads in some litters of tamoxifen-treated mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:206626 )

N • fasted and fed tamoxifen-treated mice exhibit normal glucose and phosphate serum levels

increased circulating parathyroid hormone level ( J:206626 )

• in tamoxifen-treated mice

increased circulating calcium level ( J:206626 )

• in tamoxifen-treated mice

improved glucose tolerance ( J:206626 )

• tamoxifen-treated mice exhibit increased capacity for glucose disposal compared with control mice

increased insulin sensitivity ( J:206626 )

• tamoxifen-treated mice exhibit increased hypoglycemic response to exogenous insulin compared with control mice

increased vitamin D level ( J:206626 )

• elevated 1,25(OH)2D in tamoxifen-treated mice

growth/size/body

decreased body size ( J:206626 )

• in tamoxifen-treated mice

decreased body weight ( J:206626 )

• in tamoxifen-treated mice

weight loss ( J:206626 )

• in tamoxifen-treated mice

integument

decreased subcutaneous adipose tissue amount ( J:206626 )

• in tamoxifen-treated mice

abnormal coat/hair pigmentation ( J:206626 )

• greying hair in tamoxifen-treated mice

alopecia ( J:206626 )

• in tamoxifen-treated mice

adipose tissue

decreased subcutaneous adipose tissue amount ( J:206626 )

• in tamoxifen-treated mice

decreased white adipose tissue amount ( J:206626 )

• in tamoxifen-treated mice

skeleton

kyphosis ( J:206626 )

• in tamoxifen-treated mice

behavior/neurological

abnormal reflex ( J:206626 )

• abnormal hindlimb reflex in tamoxifen-treated mice

pigmentation

abnormal coat/hair pigmentation ( J:206626 )

• greying hair in tamoxifen-treated mice

endocrine/exocrine glands

abnormal sex gland morphology ( J:206626 )

• small gonads in some litters of tamoxifen-treated mice

cellular

azoospermia ( J:206626 )

♂ • in tamoxifen-treated mice