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Phenotypes Associated with This Genotype
Genotype
MGI:5558945
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf14Tg(tetO-MAPT*P301L)4510Kha mutation (2 available); any Fgf14 mutation (19 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• progressive decrease in percent of time spent freezing in response to unconditioned stimulus beginning at 2 months of age
• progressive decrease in percent of time spent freezing in response to conditioned stimulus beginning at 6 months of age
• amount of time spent in open arms of elevated plus maze is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months
• higher ratio of time spent in open not closed arms relative to nontransgenic mice at 10 months of age, but not 2 or 6 months
• exploration of light chamber is increased relative to nontransgenic mice at 6 months of age, but not 2 or 10 months
• higher ratio of time spent in light not dark relative to nontransgenic miceat 10 months of age, but not 2 or 6 months
• decreased tendency to explore the center of the open field relative to nontransgenic mice
• mice exhibit progressive hyperactivity in open field analysis and elevated plus maze
• total distance travelled in open field assay is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months
• average speed is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months
• total time spent immobile is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months

nervous system
• neurofibrilliary tangles are observed by immunostaining in the CA1 region of the hippocampus beginning at 6 months of age and progressing to an extensive pathology by 11 months of age
• neurofibrilliary tangles are observed by immunostaining in the amygdala beginning at 2 months of age and progressing to an extensive pathology by 10 months of age
• tau burden increases with age in the amygdala and CA1 region of the hippocampus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
OMIM:600795
J:207366


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory