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Phenotypes Associated with This Genotype
Genotype
MGI:5558940
Allelic
Composition
Megf8tm1.2Ddg/Megf8tm1.2Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Megf8tm1.2Ddg mutation (1 available); any Megf8 mutation (97 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• radial and ulnar nerve development is normal
• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice
• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

limbs/digits/tail
N
• mice exhibit normal limb maturity

cellular
• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory