Phenotypes Associated with This Genotype

Genotype
MGI:5558065

• Allelic Composition: Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow

hematopoietic system

anemia ( J:207446 )

abnormal bone marrow cell morphology/development ( J:207446 )

• lethally irradiated animals transplanted with mutant bone marrow and treated with doxycycline show erythroid progenitor arrest and megakaryocyte differentiation defects in a wild-type bone marrow environment, but do not exhibit anemia or cytopenia; defects are blood cell-autonomous

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow

absent erythroid progenitor cell ( J:207446 )

• after induction, no erythroid precursors at or beyond the proerythroblast (monopotent progenitors) stage are detected in the bone marrow

abnormal megakaryocyte progenitor cell morphology ( J:207446 )

• numbers of bipotent megakaryocyte and erythrocyte progenitor cells (pre-MegEs) are increased in bone marrow

decreased hemoglobin content ( J:207446 )

• moribund animals have hemoglobin levels of 1-2 g/dl

thrombocytopenia ( J:207446 )

• moribund animals have severe thrombocytopenia; some animals have no detectable platelets

absent platelets ( J:207446 )

• in some animals

mortality/aging

postnatal lethality, complete penetrance ( J:207446 )

• pI:pC activation of cre-mediated excision in animals 4-8 weeks of age is lethal in less than 3 weeks