Phenotypes Associated with This Genotype

Genotype
MGI:5555976

• Allelic Composition: Mir210^tm1.1Wtsi/Mir210^tm1.1Wtsi
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:205868 )

N • mice exhibit normal baseline serum IgM, IgG1, IgG3 and IgA levels and the ability to mount an antibody response to T-dependent and T- independent antigens

decreased germinal center B cell number ( J:205868 )

• in aged mice

increased anti-nuclear antigen antibody level ( J:205868 )

• at 5 months

increased anti-chromatin antibody level ( J:205868 )

• at 10 to 11 months

increased anti-double stranded DNA antibody level ( J:205868 )

• at 10 to 11 months

hematopoietic system

decreased germinal center B cell number ( J:205868 )

• in aged mice