Mir210^tm1.1Wtsi
Targeted Allele Detail

Summary

• Symbol: Mir210^tm1.1Wtsi
• Name: microRNA 210; targeted mutation 1.1, Wellcome Trust Sanger Institute
• MGI ID: MGI:5555932
• Synonyms: Mir210^{tm1.1(mirKO)Wtsi}
• Gene: Mir210 Location: Chr7:140801297-140801406 bp, - strand Genetic Position: Chr7, 86.52 cM
• Alliance: Mir210^tm1.1Wtsi page

Mutation origin

• Mutant Cell Line: mirKO_ES_PuDtk_1A1
• Germline Transmission: Earliest citation of germline transmission: J:205868
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion Vector: PGK_EM7_PuDtk_bGHpA
• Mutation details: The insertion of the PGK_EM7_PuDtk_bGHpA cassette created a deletion of size 237 starting at position 148407458 and ending at position 148407221 of Chromosome 7 (Genome Build 37). This deletion eliminates the DNA sequence for this microRNA. The cassette is composed of a loxP site followed by an F3 site followed by a PGK-puromycin-delta-tk cassette, a loxP site and finally an FRT site. Cre-mediated recombination removed the selection cassette. (J:205868)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir210 Mutation: 8 strains or lines available

References

• Original: J:205868 Mok Y, et al., MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production. J Immunol. 2013 Sep 15;191(6):3037-48
• All: 3 reference(s)