Analysis Tools
renal/urinary system
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• when tamoxifen is administered at E12.5, mutant kidneys have about half the number of glomeruli (48%) at E19.5
• glomerulus number does not recover as well as kidney size with numbers only 57.6% of normal at P50
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• when tamoxifen is administered at E12.5, fetuses develop severe renal hypoplasia by E14.5, with kidney growth rate reduced relative to wild-type
• nephrogenic zone appears normal at E19.5
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small kidney
(
J:206853
)
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• when tamoxifen is administered at E12.5, at E19.5 kidneys are 55.7% of normal size (based on maximal cross-sectional area); normal gross organization into cortex, medulla and papilla remains
• recovery from tamoxifen treatment at E12.5 is observed postnatally with kidney size reaching 70.4% of control size at P14 and 89.3% at P50
• with tamoxifen treatment at E14.5, resulting kidney morphology is similar at birth with reduced hypoplasia; kidneys are 89% of control size
• when tamoxifen is administered at E9.5, about half the fetuses have severe renal hypoplasia with kidneys about 46.6% of the size of controls
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• when tamoxifen is administered at E9.5, about half the fetuses display renal agenesis at E18.5
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