Phenotypes for Apoe Klf15 MGI:5552968 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Klf15^tm1Jain/Klf15^tm1Jain
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (34 available); any Apoe mutation (163 available)
Klf15^tm1Jain mutation (0 available); any Klf15 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:203920 )

• in mice fed a high fat diet compared with Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased circulating cholesterol level ( J:203920 )

• in mice fed a high fat diet compared with Apoe^tm1Unc homozygotes

increased circulating triglyceride level ( J:203920 )

• in mice fed a high fat diet compared with Apoe^tm1Unc homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:203920 )

• greater plaque size in mice fed a high fat diet or standard chow compared with Apoe^tm1Unc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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