Phenotypes Associated with This Genotype

Genotype
MGI:5552962

• Allelic Composition: Fas^lpr/Fas^lpr; Itfg2^{Gt(OST215121)Lex}/Itfg2^{Gt(OST215121)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:205951 )

• worse than in Fas^lpr homozygotes

increased double-negative T cell number ( J:205951 )

• increased faster in the blood and to a higher proportion than in Fas^lpr homozygotes

decreased B cell number ( J:205951 )

• decreased circulating B cells for the first 13 weeks of age compared with Fas^lpr homozygotes

increased IgG2a level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

increased IgM level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

enlarged lymph nodes ( J:205951 )

• worse than in Fas^lpr homozygotes

increased susceptibility to systemic lupus erythematosus ( J:205951 )

• more severe autoimmune disease development with inflammatory cell infiltration of the kidney and hypertrophy in the lymphoid organs compared with Fas^lpr homozygotes

increased anti-nuclear antigen antibody level ( J:205951 )

• compared with Fas^lpr homozygotes

increased anti-double stranded DNA antibody level ( J:205951 )

• compared with Fas^lpr homozygotes

homeostasis/metabolism

increased urine protein level ( J:205951 )

• compared with Fas^lpr homozygotes

renal/urinary system

increased urine protein level ( J:205951 )

• compared with Fas^lpr homozygotes

hematopoietic system

enlarged spleen ( J:205951 )

• worse than in Fas^lpr homozygotes

increased double-negative T cell number ( J:205951 )

• increased faster in the blood and to a higher proportion than in Fas^lpr homozygotes

decreased B cell number ( J:205951 )

• decreased circulating B cells for the first 13 weeks of age compared with Fas^lpr homozygotes

increased IgG2a level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

increased IgM level ( J:205951 )

• from 19 weeks compared with Fas^lpr homozygotes

growth/size/body

enlarged spleen ( J:205951 )

• worse than in Fas^lpr homozygotes