Phenotypes Associated with This Genotype

Genotype
MGI:5551751

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺; Tg(Pax2-cre)1Akg/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thymic aplasia, nasal malformations, and eye, pharyngeal and ear defects in Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Foxg1^tm1(cre)Skm/Foxg1⁺ mice and microcephaly, ocular and ear defects in Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tg(Pax2-cre)1Akg/0 mice

mortality/aging

perinatal lethality, complete penetrance ( J:204435 )

hearing/vestibular/ear

abnormal cochlea morphology ( J:204435 )

• hypoplastic to varying degrees, but enlarged in two instances

abnormal semicircular canal morphology ( J:204435 )

• fusion plates are not joined at E12.25

• however, they have partially recovered by E14.5

abnormal common crus morphology ( J:204435 )

• enlarged at E14.5

absent lateral semicircular canal ( J:204435 )

absent utricle ( J:204435 )

absent vestibular saccule ( J:204435 )

abnormal endolymphatic duct morphology ( J:204435 )

• enlarged at E14.5