Phenotypes Associated with This Genotype

Genotype
MGI:5551395

• Allelic Composition: H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺; Tg(Wnt1-GAL4)11Rth/0
• Genetic Background: involves: C57BL/6J * CBA/J * Swiss albino

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:192250 )

• males spend more time in the center of the open field than wild-type males; no differences are observed with females of either genotype

abnormal spatial learning ( J:192250 )

• in the Morris water maze probe test, females show significant impairment relative to controls; males show no difference

abnormal anxiety-related response ( J:192250 )

• males spend more time in the open center of the elevated plus maze compared to wild-type males; no differences are observed in female mutants or controls

increased locomotor activity ( J:192250 )

• males and females exhibit significantly increased locomotor activity

abnormal nest building behavior ( J:192250 )

• mice show less nest building behavior than wild-type during a 3 day observation period

abnormal social investigation ( J:192250 )

• mutant males show decreased social interactions relative to wild-type with lower total number and duration of interactions with unfamiliar mice; females show no significant differences from wild-type

nervous system

abnormal midbrain development ( J:192250 )

• cholinergic and glutamatergic fibers from the medial habenula nucleus are disordered in males and females; immunolabeling shows irregular tracts in the interpeduncular nucleus