Phenotypes Associated with This Genotype

Genotype
MGI:5550267

• Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn; Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:205692 )

• due to inflammatory disease

immune system

increased eosinophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased neutrophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased CD4-positive, alpha-beta T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased interleukin-2 secretion ( J:205692 )

• compared with Il4^tm1Cgn homozygotes

increased inflammatory response ( J:205692 )

• at 12, but not 6, weeks

esophageal inflammation ( J:205692 )

lung inflammation ( J:205692 )

digestive/alimentary system

esophageal epithelium hyperplasia ( J:205692 )

esophageal inflammation ( J:205692 )

respiratory system

lung inflammation ( J:205692 )

lung epithelium hyperplasia ( J:205692 )

hematopoietic system

increased eosinophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased neutrophil cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues

increased CD4-positive, alpha-beta T cell number ( J:205692 )

• increased percent in esophagus and lung mucosal tissues