Phenotypes for Cyp11b2 Nr5a1 MGI:5550087 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr5a1^tm2Klp/Nr5a1^tm2Klp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp11b2^{tm1.1(cre)Brlt} mutation (0 available); any Cyp11b2 mutation (41 available)
Nr5a1^tm2Klp mutation (2 available); any Nr5a1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal adrenal gland zona glomerulosa morphology ( J:204614 )

• zone is disorganized with pleomorphic nuclei, whereas inner zona fasciculata appears normal in young and old mice

• cells in the zona granulosa dedifferentiated with Nr5a1 deletion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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