Phenotypes Associated with This Genotype

Genotype
MGI:5547938

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:205518 )

• when mice older than 6 weeks are given systemic tamoxifen treatment by intraperitoneal delivery, mice develop multiple tumors (avg. 3.9 per mouse) with 100% penetrance within 1-2 months; median tumor-free survival is 44 days

• tumors develop at various locations, including clinically relevant sites including the orbit

increased sarcoma incidence ( J:205518 )

• tamoxifen treated mice develop tumors displaying a histological spectrum ranging from undifferentiated pleomorphic sarcoma (UPS) to rhabdomyosarcoma (RMS)

• tumors mimic embryonic RMS, pleomorphic RMS, or myogenic or nonmyogenic UPS

• sarcomas can appear in the body wall (37%), the extremities (31%), head and neck (23%), with some being subcutaneous (9%)