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Phenotypes Associated with This Genotype
Genotype
MGI:5546225
Allelic
Composition		 Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1.1Vlcg mutation (0 available); any Adgra2 mutation (44 available)
Adgra2tm2.1Vlcg mutation (0 available); any Adgra2 mutation (44 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal brain vasculature morphology ( J:200671 )
• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice
• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124tm1.1Vlcg homozygotes

nervous system
abnormal brain vasculature morphology ( J:200671 )
• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice
• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124tm1.1Vlcg homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory