Phenotypes Associated with This Genotype

Genotype
MGI:5544101

• Allelic Composition: Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:204869 )

• mice die within the first week after birth

homeostasis/metabolism

increased circulating glucose level ( J:204869 )

• at P1

hyperglycemia ( J:204869 )

• severe

endocrine/exocrine glands

decreased pancreatic alpha cell number ( J:204869 )

decreased pancreatic beta cell number ( J:204869 )

increased pancreatic epsilon cell number ( J:204869 )