Phenotypes Associated with This Genotype

Genotype
MGI:5544088

• Allelic Composition: Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺; Tg(Pax6-cre,GFP)2Pgr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spatially localized Edn2 expression results in local inhibition of retinal vascular development in Igs1^{tm11(CAG-Bgeo,-Edn2)Nat}/Igs1⁺ Tg(Pax6-cre,GFP)2Pgr/0 mice

vision/eye

abnormal retina morphology ( J:201133 )

• regional thinning of all three layers in the peripheral retina

abnormal retina vasculature morphology ( J:201133 )

• intraretinal capillaries are rarely seen in the peripheral retina

• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina

thin retina ganglion layer ( J:201133 )

• in the peripheral retina

thin retina inner nuclear layer ( J:201133 )

• in the peripheral retina

thin retina outer nuclear layer ( J:201133 )

• in the peripheral retina

homeostasis/metabolism

hypoxia ( J:201133 )

• in the peripheral retina

cardiovascular system

abnormal retina vasculature morphology ( J:201133 )

• intraretinal capillaries are rarely seen in the peripheral retina

• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina