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Phenotypes Associated with This Genotype
Genotype
MGI:5543694
Allelic
Composition		 Csnk1a1tm1.1Ybn/Csnk1a1+
Tg(Vil1-cre/ERT2)23Syr/0
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129 * C57BL/6 * CD-1 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csnk1a1tm1.1Ybn mutation (1 available); any Csnk1a1 mutation (38 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased carcinoma incidence ( J:204886 )
• within 6 months, 7 of 9 tamoxifen-treated mice develop invasive carcinomas that permeates the bowel muscular wall into the subserosal fat with some involvement of the serosal surface (stage T4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory