Phenotypes Associated with This Genotype

Genotype
MGI:5543250

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Kras^tm4Tyj/Kras⁺; Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal mismatch repair ( J:204653 )

• numbers of stained spots in intestines is not increased compared to mice without the Kras allele, but size of stained patches increases suggesting sporadic cre activation of Kras which might have a selective advantage for mutant stem cells resulting in clonal expansion and crypt fission

neoplasm

increased lung tumor incidence ( J:204653 )

• animals become moribund at 5 weeks of age due to high lung tumor burden

cellular

abnormal mismatch repair ( J:204653 )

• numbers of stained spots in intestines is not increased compared to mice without the Kras allele, but size of stained patches increases suggesting sporadic cre activation of Kras which might have a selective advantage for mutant stem cells resulting in clonal expansion and crypt fission

respiratory system

increased lung tumor incidence ( J:204653 )

• animals become moribund at 5 weeks of age due to high lung tumor burden