Phenotypes Associated with This Genotype

Genotype
MGI:5538721

• Allelic Composition: Spo11^tm1.1Gvpc/Spo11^tm3Rdco
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absence of germ cells beyond the spermatocyte stage and small ovaries with diminished number of follicles in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc mice and absence of ovarian follicles in Spo11^tm1.1Gvpc/Spo11^tm3Rdco mice

mortality/aging

early reproductive senescence ( J:202231 )

♀ • while young female mice produce progeny, no viable litters are obtained in mice older than 6 months

reproductive system

azoospermia ( J:202231 )

♂ • no germ cells beyond the spermatocyte stage

abnormal X-Y chromosome synapsis during male meiosis ( J:202231 )

♂

arrest of male meiosis ( J:202231 )

♂ • with a failure of complete synapsis

decreased mature ovarian follicle number ( J:202231 )

♀

small ovary ( J:202231 )

♀

small testis ( J:202231 )

♂

early reproductive senescence ( J:202231 )

♀ • while young female mice produce progeny, no viable litters are obtained in mice older than 6 months

male infertility ( J:202231 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes

• deficiency of double strand breaks at the chromosomal ends

cellular

azoospermia ( J:202231 )

♂ • no germ cells beyond the spermatocyte stage

abnormal X-Y chromosome synapsis during male meiosis ( J:202231 )

♂

arrest of male meiosis ( J:202231 )

♂ • with a failure of complete synapsis

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes

• deficiency of double strand breaks at the chromosomal ends

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:202231 )

♀

small ovary ( J:202231 )

♀

small testis ( J:202231 )

♂