Phenotypes for Psmc3ip Spo11 MGI:5538720 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmc3ip^tm1Rdco mutation (0 available); any Psmc3ip mutation (7 available)
Spo11^tm1.1Gvpc mutation (0 available); any Spo11 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The number of meiotic double stranded breaks is reduced in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc and Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco females

cellular

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

• deficiency of double strand breaks at the chromosomal ends

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

• deficiency of double strand breaks at the chromosomal ends

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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