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Phenotypes Associated with This Genotype
Genotype
MGI:5538720
Allelic
Composition		 Psmc3iptm1Rdco/Psmc3iptm1Rdco
Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmc3iptm1Rdco mutation (0 available); any Psmc3ip mutation (6 available)
Spo11tm1.1Gvpc mutation (0 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

The number of meiotic double stranded breaks is reduced in Spo11tm1.1Gvpc/Spo11tm1.1Gvpc and Spo11tm1.1Gvpc/Spo11tm1.1Gvpc Psmc3iptm1Rdco/Psmc3iptm1Rdco females

cellular
abnormal double-strand DNA break repair ( J:202231 )
• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes
• deficiency of double strand breaks at the chromosomal ends

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:202231 )
• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes
• deficiency of double strand breaks at the chromosomal ends

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory