Phenotypes Associated with This Genotype

Genotype
MGI:5538719

• Allelic Composition: Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absence of germ cells beyond the spermatocyte stage and small ovaries with diminished number of follicles in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc mice and absence of ovarian follicles in Spo11^tm1.1Gvpc/Spo11^tm3Rdco mice

reproductive system

absent mature ovarian follicles ( J:202231 )

♀

small ovary ( J:202231 )

♀ • more so than in Spo11^tm3.1Rdco homozygotes

abnormal uterus development ( J:202231 )

♀ • underdeveloped

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

cellular

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes; more so in oocytes than spermatocytes

endocrine/exocrine glands

absent mature ovarian follicles ( J:202231 )

♀

small ovary ( J:202231 )

♀ • more so than in Spo11^tm3.1Rdco homozygotes