Phenotypes Associated with This Genotype

Genotype
MGI:5538340

• Allelic Composition: Slc12a2^K842*/Slc12a2^K842*
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired balance ( J:201156 )

head tossing ( J:201156 )

hyperactivity ( J:201156 )

• treatment with haloperidol alleviates hyperactivity without affecting grooming behavior in mutants at a dose that does not affect the behavior of control littermates

circling ( J:201156 )

hearing/vestibular/ear

abnormal inner ear morphology ( J:201156 )

• collapse of the membranes of the vestibular compartments

collapsed Reissner membrane ( J:201156 )

abnormal crista ampullaris morphology ( J:201156 )

• cristae degeneration

utricular degeneration ( J:201156 )

vestibular saccular degeneration ( J:201156 )

deafness ( J:201156 )

• profound