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Phenotypes Associated with This Genotype
Genotype
MGI:5532830
Allelic
Composition
Sidt2tm1.1Hzha/Sidt2tm1.1Hzha
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sidt2tm1.1Hzha mutation (0 available); any Sidt2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Increase in body size of Sidt2tm1.1Hzha/Sidt2tm1.1Hzha adult mice

cellular
• some ERs show degradation of the tube net structure, with scattered plum blossom-like ribosome particles and swelling of the smooth ER in some areas
• mice show hepatic endoplasmic reticulum (ER) stress, with liver showing damage to the ER, the rough ER showing swelling of the cavity, beaded changes in some lumen, balloon-shaped swelling, different degrees of reduction in the number of ribosomes attached to the outer surface, and irregular cavity configuration

homeostasis/metabolism
N
• mice exhibit normal insulin sensitivity
• decreased insulin granule release in male mice
• in random fed and fasted male mice at 6 months
• in both oral and intraperitoneal glucose tolerance tests of male mice at 6 months
• in male mice during glucose tolerance test at 4 and 8 weeks
• increase in serum levels of triglyceride from 3 months of age
• in male mice at 4 and 8 weeks
• increase in free fatty acids from 3 months of age which increases further at 6 months

growth/size/body
• in male mice after 5 weeks
• however, female mice exhibit normal appearance
• in male mice after 5 weeks
• however, female mice exhibit normal weight

immune system
• mice exhibit a large number of inflammatory cells at the hepatic lobule and portal area
• mice exhibit a large number of macrophages in the hepatic blood sinus area and chemotaxis of macrophages towards the endothelium

endocrine/exocrine glands
• more insulin secretory granules due to decreased granule release in male mice
• decreased insulin granule release in male mice

liver/biliary system
• mice exhibit a large number of inflammatory cells at the hepatic lobule and portal area
• mice exhibit a large number of macrophages in the hepatic blood sinus area and chemotaxis of macrophages towards the endothelium
• lobular structure of the liver is disordered
• increase in free fatty acids from 3 months of age which increases further at 6 months
• nonuniform size and morphology of liver cells
• ballooning degeneration of some liver cells
• swelling of some liver cells, with large vacuolar lipid droplets in the cytoplasm
• hepatic cell necrosis, seen as nuclear pyknosis and chromatin margination
• mice develop severe hepatic steatosis, with a yellower and greasier liver at 6 months of age
• almost all liver cells show steatosis
• mice exhibit a large number of inflammatory cells at the hepatic lobule and portal area, with part of the region replaced by fibrosis connective tissue

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nonalcoholic fatty liver disease DOID:0080208 OMIM:613282
OMIM:613387
J:236042


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory