Analysis Tools
cellular
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• some ERs show degradation of the tube net structure, with scattered plum blossom-like ribosome particles and swelling of the smooth ER in some areas
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• hepatic cell necrosis, seen as nuclear pyknosis and chromatin margination
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• mice show hepatic endoplasmic reticulum (ER) stress, with liver showing damage to the ER, the rough ER showing swelling of the cavity, beaded changes in some lumen, balloon-shaped swelling, different degrees of reduction in the number of ribosomes attached to the outer surface, and irregular cavity configuration
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homeostasis/metabolism
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• mice exhibit normal insulin sensitivity
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• decreased insulin granule release in male mice
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• in random fed and fasted male mice at 6 months
• in both oral and intraperitoneal glucose tolerance tests of male mice at 6 months
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• in male mice during glucose tolerance test at 4 and 8 weeks
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• increase in serum levels of triglyceride from 3 months of age
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• in male mice at 4 and 8 weeks
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• increase in free fatty acids from 3 months of age which increases further at 6 months
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growth/size/body
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• in male mice after 5 weeks
• however, female mice exhibit normal appearance
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• in male mice after 5 weeks
• however, female mice exhibit normal weight
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immune system
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• mice exhibit a large number of inflammatory cells at the hepatic lobule and portal area
• mice exhibit a large number of macrophages in the hepatic blood sinus area and chemotaxis of macrophages towards the endothelium
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endocrine/exocrine glands
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• more insulin secretory granules due to decreased granule release in male mice
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• in male mice
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• decreased insulin granule release in male mice
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liver/biliary system
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• mice exhibit a large number of inflammatory cells at the hepatic lobule and portal area
• mice exhibit a large number of macrophages in the hepatic blood sinus area and chemotaxis of macrophages towards the endothelium
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• lobular structure of the liver is disordered
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• hepatic cell necrosis, seen as nuclear pyknosis and chromatin margination
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• increase in free fatty acids from 3 months of age which increases further at 6 months
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• nonuniform size and morphology of liver cells
• ballooning degeneration of some liver cells
• swelling of some liver cells, with large vacuolar lipid droplets in the cytoplasm
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• mice develop severe hepatic steatosis, with a yellower and greasier liver at 6 months of age
• almost all liver cells show steatosis
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• mice exhibit a large number of inflammatory cells at the hepatic lobule and portal area, with part of the region replaced by fibrosis connective tissue
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| metabolic dysfunction-associated steatotic liver disease | DOID:0080208 |
OMIM:613282 OMIM:613387 |
J:236042 | |
