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Phenotypes Associated with This Genotype
Genotype
MGI:5532665
Allelic
Composition		 Tcratm1Cgn/Tcratm1Mass
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Cgn mutation (0 available); any Tcra mutation (102 available)
Tcratm1Mass mutation (0 available); any Tcra mutation (102 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell number ( J:201417 )
• uninduced mice exhibit an increase in tetramer+ T cells due to leaky cre expression
abnormal T cell physiology ( J:201417 )
• TCR-switched T cells treated with pIpC induce sterile inflammation in recipient mice possibly due to autoimmune activation
• however, recipient mice treated with galactosylceramide do not exhibit induction of NK T cell differentiation of TCR-switched tetramer+ T cells

hematopoietic system
increased T cell number ( J:201417 )
• uninduced mice exhibit an increase in tetramer+ T cells due to leaky cre expression
abnormal T cell physiology ( J:201417 )
• TCR-switched T cells treated with pIpC induce sterile inflammation in recipient mice possibly due to autoimmune activation
• however, recipient mice treated with galactosylceramide do not exhibit induction of NK T cell differentiation of TCR-switched tetramer+ T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory