Phenotypes Associated with This Genotype

Genotype
MGI:5529811

• Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok; Tg(CAG-EGFP/Map1lc3b)53Nmz/0; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cataract development in Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 mice

homeostasis/metabolism

impaired autophagy ( J:198392 )

• absent in lens fiber cells

vision/eye

abnormal lens fiber morphology ( J:198392 )

• absent autophagy in lens fiber cells

• disorganized in the cortical region of aged mice

• however, organelle degradation is normal

cataract ( J:198392 )

• by 6 to 9 months that develops progressively with age

• severe, bilateral at 21 months

• with accumulation of insoluble oxidized proteins and crystallins

cellular

impaired autophagy ( J:198392 )

• absent in lens fiber cells