Phenotypes Associated with This Genotype

Genotype
MGI:5529619

• Allelic Composition: Plvap^{tm1e(EUCOMM)Hmgu}/Plvap^{tm1e(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Plvap^{tm1e(EUCOMM)Hmgu}
• Cell Lines: HEPD0550_4_E12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:203907 )

• Background Sensitivity: no mice on a coisogenic C57BL/6N background are observed after E17.5 unlike mice on a mixed C57BL/6N and FVB/N background that survive up to 4 weeks

cardiovascular system

abnormal capillary morphology ( J:203907 )

• capillaries lack caveolae with stomatal diaphragms and exhibit incomplete endothelial walls comapred with wild-type mice

ventricular septal defect ( J:203907 )

• at E16.5

thin ventricular wall ( J:203907 )

• at E16.5

hemorrhage ( J:203907 )

• at E16.5 with accumulation of extracellular erythrocytes

• extensive, non-specific focal at E17.5

hematopoietic system

anemia ( J:203907 )

abnormal erythrocyte morphology ( J:203907 )

• accumulation of extracellular erythrocytes at E16.5

increased nucleated erythrocyte cell number ( J:203907 )

• at E14.5, E16.5 and E17.5

homeostasis/metabolism

edema ( J:203907 )

• severe total body at E17.5

skin edema ( J:203907 )

• extending from the neck to the lower back at E16.5 with accumulation of extracellular erythrocytes

integument

skin edema ( J:203907 )

• extending from the neck to the lower back at E16.5 with accumulation of extracellular erythrocytes

pallor ( J:203907 )