About   Help   FAQ
Targeted Allele Detail
Symbol: Plvaptm1e(EUCOMM)Hmgu
Name: plasmalemma vesicle associated protein; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4434827
Gene: Plvap  Location: Chr8:71950409-71964396 bp, - strand  Genetic Position: Chr8, 34.43 cM
Alliance: Plvaptm1e(EUCOMM)Hmgu page
IMPC: Plvap gene page
Mutant Cell Lines:  HEPD0550_4_A09, HEPD0550_4_A10, HEPD0550_4_A11, HEPD0550_4_A12, HEPD0550_4_B11, HEPD0550_4_B12, HEPD0550_4_C09, HEPD0550_4_C11, HEPD0550_4_C12, HEPD0550_4_D09, HEPD0550_4_D10, HEPD0550_4_D11, HEPD0550_4_D12, HEPD0550_4_E09, HEPD0550_4_E11, HEPD0550_4_E12, HEPD0550_4_F10, HEPD0550_4_F11, HEPD0550_4_F12, HEPD0550_4_G09, HEPD0550_4_G11, HEPD0550_4_G12, HEPD0550_4_H09, HEPD0550_4_H10, HEPD0550_4_H11
Germline Transmission:  Earliest citation of germline transmission: J:203907
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 71961688 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065, J:203907)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Plvap Mutation:  47 strains or lines available
Cell line HEPD0550_4_E12 was successfully used to make chimeric mice. Germline transmission was accomplished. J:203907
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory