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Phenotypes Associated with This Genotype
Genotype
MGI:5527556
Allelic
Composition		 Flot2tm1Mak/Flot2tm1Mak
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot2tm1Mak mutation (1 available); any Flot2 mutation (34 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice

neoplasm
increased mammary gland tumor incidence ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice
decreased metastatic potential ( J:203238 )
• 10-fold fewer visible macro-metastases in the lungs compared to in Tg(MMTV-PyVT)634Mul mice
• fewer micro-metastases in the lungs compared to in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice

integument
increased mammary gland tumor incidence ( J:203238 )
• as in Tg(MMTV-PyVT)634Mul mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory