Phenotypes Associated with This Genotype

Genotype
MGI:5527080

• Allelic Composition: Stip1^tm1.2Mamp/Stip1^tm1.2Mamp
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:201097 )

• no mice are present at E10.5

embryonic lethality, incomplete penetrance ( J:201097 )

• however, transgenic expression of Stip1 rescues lethality

• fewer than expected mice are present at E3.5 and E10.5

cellular

increased cell death ( J:201097 )

• in mouse embryonic fibroblasts after 8 to 10 days in culture

increased embryonic tissue cell apoptosis ( J:201097 )

• in E10.5 embryos

decreased fibroblast proliferation ( J:201097 )

• in mouse embryonic fibroblasts

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in mouse embryonic fibroblasts after 8 to 10 days in culture

embryo

increased embryonic tissue cell apoptosis ( J:201097 )

• in E10.5 embryos

abnormal limb bud morphology ( J:201097 )

• poorly formed

abnormal neural tube morphology ( J:201097 )

• poorly formed

abnormal placenta physiology ( J:201097 )

• acute inflammation in and around the placental labyrinth without infection unlike in wild-type mice

limbs/digits/tail

abnormal limb bud morphology ( J:201097 )

• poorly formed

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in mouse embryonic fibroblasts after 8 to 10 days in culture

nervous system

abnormal neural tube morphology ( J:201097 )

• poorly formed

immune system

increased acute inflammation ( J:201097 )

• acute inflammation in and around the placental labyrinth without infection unlike in wild-type mice